Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis
نویسندگان
چکیده
منابع مشابه
Inhibition of hepatic alcohol dehydrogenase by bilirubin.
Human bile is capable of inhibiting, in vitro, the action of human and equine liver alcohol dehydrogenase. The effect is attributable mainly to bilirubin conjugates. Sodium deoxycholate had negligible inhibitory ability. Preliminary evidence indicates that the mechanism of this inhibition of alcohol dehydrogenase is related to the capability of bilirubin for complex formation with the zinc ion....
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a w C t a g o l ubstantial improvements in the treatment of hronic liver disease have accelerated interest in unovering the mechanisms underlying hepatic fibrosis nd its resolution. Activation of resident hepatic stelate cells into proliferative, contractile, and fibrogenic ells in liver injury remains a dominant theme driving he field. However, several new areas of rapid rogress in the past 5–...
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Alcohol dehydrogenase activity was measured in samples of liver tissue from a group of alcoholic and non-alcoholic subjects to determine whether decreased liver alcohol dehydrogenase activity is a consequence of ethanol consumption or liver damage. The alcoholic patients were classified further into the following groups: control subjects with no liver disease (group 1), subjects with non-cirrho...
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On a worldwide perspective chronic liver diseases (CLDs) are very common pathologic conditions which are characterized by reiteration of hepatocyte injury that is mainly induced by chronic infection by hepatitis B and C viruses (HBV and HCV), autoimmune injury and metabolic and/or toxic/drug – induced causes, with chronic alcohol consumption being predominant particularly in western countries. ...
متن کاملHepatic fibrogenesis requires sympathetic neurotransmitters.
BACKGROUND AND AIMS Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be regulated by the sympathetic nervous system (SNS) but the mechanisms involved are unclear. METHODS We studied cultured HSC and intact mice with liver injury to test the hypothesis that HSC respond to and produce SNS neurotransmitters to promote ...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2018
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.118.249425